Gallium in PDB 9ohs: Crystal Structure of Human Fto in Complex with Ga(III) and Ascorbate

All present enzymatic activity of Crystal Structure of Human Fto in Complex with Ga(III) and Ascorbate:
1.14.11.53;

The structure of Crystal Structure of Human Fto in Complex with Ga(III) and Ascorbate, PDB code: 9ohs was solved by L.O.Calzini, J.S.Mugridge, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.22 / 3.07
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	143.872, 143.872, 85.241, 90, 90, 120
R / Rfree (%)	19.3 / 25.3

The binding sites of Gallium atom in the Crystal Structure of Human Fto in Complex with Ga(III) and Ascorbate (pdb code 9ohs). This binding sites where shown within 5.0 Angstroms radius around Gallium atom.
In total only one binding site of Gallium was determined in the Crystal Structure of Human Fto in Complex with Ga(III) and Ascorbate, PDB code: 9ohs:

Gallium binding site 1 out of 1 in the Crystal Structure of Human Fto in Complex with Ga(III) and Ascorbate


Mono view


Stereo pair view

A full contact list of Gallium with other atoms in the Ga binding site number 1 of Crystal Structure of Human Fto in Complex with Ga(III) and Ascorbate within 5.0Å range: probe atom residue distance (Å) B Occ A:Ga601 b:89.0 occ:1.00 O2 A:ASC602 2.0 139.8 1.0 O3 A:ASC602 2.0 137.4 1.0 OD1 A:ASP233 2.1 103.5 1.0 NE2 A:HIS307 2.3 97.5 1.0 C3 A:ASC602 2.4 138.3 1.0 NE2 A:HIS231 2.4 85.5 1.0 C2 A:ASC602 2.4 139.3 1.0 CG A:ASP233 3.0 103.3 1.0 CE1 A:HIS231 3.0 86.3 1.0 CE1 A:HIS307 3.2 96.5 1.0 OD2 A:ASP233 3.2 105.0 1.0 CD2 A:HIS307 3.3 98.7 1.0 CD2 A:HIS231 3.5 83.9 1.0 C4 A:ASC602 3.8 138.1 1.0 C1 A:ASC602 3.9 140.0 1.0 ND1 A:HIS231 4.2 85.5 1.0 ND1 A:HIS307 4.3 97.4 1.0 CG A:HIS307 4.4 98.8 1.0 CB A:ASP233 4.4 101.3 1.0 O4 A:ASC602 4.5 139.2 1.0 CG A:HIS231 4.5 84.0 1.0 NH1 A:ARG322 4.6 87.9 1.0 C6 A:ASC602 4.6 136.0 1.0 O1 A:ASC602 4.8 141.1 1.0 C5 A:ASC602 4.8 136.8 1.0 CA A:ASP233 4.8 99.8 1.0

L.O.Calzini, M.Warminski, J.Kowalska, J.Jemielity, J.S.Mugridge. Differential Control of Rna Demethylase Activity and Selectivity By Cofactor Ascorbate Biorxiv 2025.
ISSN: ISSN 2692-8205
DOI: 10.1101/2025.05.06.652568